Need for randomised trials

Need for expertise based randomised controlled trials.

Carotid artery stenting:the need for randomised trials.

Endovascular treatment for carotid artery stenosis avoids some of the complications of carotid endarterectomy, but has not been widely accepted. Concerns about the risks and benefits of endovascular treatment led to the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS). There was no difference in major outcome events between endovascular treatment and carotid endarterectomy,...

The whole truth and nothing but the truth: the need for full reporting of randomised trials

The use of cardiac output monitoring to guide fluid and inotropic therapy in surgical patients has remained a controversial topic for more than 40 years. The reasons for this are numerous and complex, but key amongst them is the interplay between poor research methodology and the likely selective reporting of randomised trials. In this issue of Perioperative Medicine, we find a very unusual rep...

Fluid Resuscitation in Malaria: The Need for New Randomised Clinical Trials

Very little clinical research has been conducted on how to manage children with severemalaria, despite it accounting for the deaths of around 1 million children each year in Africa alone. Antimalarial drugs remain the mainstay of treatment (and are the subject of several current or planned clinical trials), but there is increasing debate around aspects of supportive care and the treatment of co...

Exercise and cardiovascular benefit in subjects with COPD: the need for randomised trials.

References 1 Camp PG, Ramirez-Venegas A, Sansores RH, et al. COPD phenotypes in biomass smokeversus tobacco smokeexposed Mexican women. Eur Respir J 2014; 43: 725–734. 2 Agustı́ A. Phenotypes and disease characterization in chronic obstructive pulmonary disease. Toward the extinction of phenotypes? Ann Am Thorac Soc 2013; 10: Suppl., S125–S130. 3 Ramı́rez-Venegas A, Sansores RH, Pérez-Padilla R, ...